The protective effects of carnosine in alcohol-induced hepatic injury in rats
Controlled trialOther animals
- Design
- Controlled trial
- Dose used in the study
- 100 mg/kg carnosine by nasogastric catheter 1 hour before each ethanol dose (ethanol 5 g/kg, three doses, given twice a day)
- What was measured
- ALT, AST, myeloperoxidase, malondialdehyde, glutathione, caspase-3, Bax and Bcl-2 expression and liver ultrastructure in rats.
What the authors reported
Alcohol raised ALT, AST, myeloperoxidase and malondialdehyde, lowered glutathione, increased caspase-3 and Bax immunoreactivity and reduced Bcl-2. Carnosine pretreatment reduced these changes and the ultrastructural liver damage seen under electron microscopy (lipid accumulation, sinusoidal dilatation, vacuolisation).
Limits of this study
Published online 2012, in print 2014. Four groups (control, alcohol, carnosine, alcohol plus carnosine); duration and animal numbers not stated in abstract. Rodents lack serum carnosinase, so oral results do not carry over to people. Full text not read.
Source
PubMed 22661399 · doi:10.1177/0748233712446722
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.