Combination products
Much carnosine research did not give carnosine itself. Sports studies give beta-alanine, the precursor, and measure the carnosine the muscle makes. Gut studies give zinc-L-carnosine (polaprezinc), a zinc complex. This page lists those studies and other pairings, grouped by the partner.
A study of a combination tests the combination. A zinc-L-carnosine result cannot be assigned to carnosine alone, or to zinc alone, unless the study included separate groups for each. A beta-alanine study tests what the body makes from beta-alanine, not a carnosine dose.
71 studies listed.
With ACE inhibitor (both groups
- The effect of 12 weeks carnosine supplementation on renal functional integrity and oxidative stress in pediatric patients with diabetic nephropathy: a randomized placebo-controlled trialRandomised controlled trialHumansWith ACE inhibitor (both groups, background therapy)
With alpha-lipoic acid (in two of three treatment groups)
- Effects of alpha-lipoic acid and L-carnosine supplementation on antioxidant activities and lipid profiles in ratsControlled trialOther animalsWith alpha-lipoic acid (in two of three treatment groups)
With anserine (2:1 anserine to carnosine
- Anserine and carnosine supplementation in the elderly: Effects on cognitive functioning and physical capacityRandomised controlled trialHumansWith anserine (2:1 anserine to carnosine, from chicken meat extract)
With anserine (3:1 anserine to carnosine formula)
- Effect of Anserine/Carnosine Supplementation on Verbal Episodic Memory in Elderly PeopleRandomised controlled trialHumansWith anserine (3:1 anserine to carnosine formula)
With anserine (as chicken breast extract)
- Oral administration of chicken breast extract increases brain carnosine and anserine concentrations in ratsLaboratory studyOther animalsWith anserine (as chicken breast extract)
With anserine (carnosine analogue
- Effect of anserine ingestion on hyperglycemia and the autonomic nerves in rats and humansControlled trialHumansOther animalsWith anserine (carnosine analogue, tested alone)
With anserine (carnosine to anserine ratio 1:3)
- Daily Carnosine and Anserine Supplementation Alters Verbal Episodic Memory and Resting State Network Connectivity in Healthy Elderly AdultsRandomised controlled trialHumansWith anserine (carnosine to anserine ratio 1:3)
With anserine (chicken breast extract containing carnosine
- Safety evaluation of chicken breast extract containing carnosine and anserineLaboratory studyOther animalsWith anserine (chicken breast extract containing carnosine and anserine)
With antipsychotic medication (background therapy)
- A preliminary, randomized, double-blind, placebo-controlled trial of L-carnosine to improve cognition in schizophreniaRandomised controlled trialHumansWith antipsychotic medication (background therapy)
With beta-alanine (carnosine precursor)
- Effect of beta-alanine on the athletic performance and blood amino acid metabolism of speed-racing Yili horsesRandomised controlled trialHorsesWith beta-alanine (carnosine precursor)
- A Systematic Risk Assessment and Meta-Analysis on the Use of Oral beta-Alanine SupplementationMeta-analysisHumansWith beta-alanine (carnosine precursor)
- beta-alanine supplementation to improve exercise capacity and performance: a systematic review and meta-analysisMeta-analysisHumansWith beta-alanine (carnosine precursor)
- Meal and beta-alanine coingestion enhances muscle carnosine loadingControlled trialHumansWith beta-alanine (carnosine precursor)
- Beta-alanine (Carnosyn) supplementation in elderly subjects (60-80 years): effects on muscle carnosine content and physical capacityRandomised controlled trialHumansWith beta-alanine (carnosine precursor)
- Effects of beta-alanine supplementation on exercise performance: a meta-analysisMeta-analysisHumansWith beta-alanine (carnosine precursor)
- Optimizing human in vivo dosing and delivery of beta-alanine supplements for muscle carnosine synthesisReviewHumansWith beta-alanine (carnosine precursor)
- Important role of muscle carnosine in rowing performanceRandomised controlled trialHumansWith beta-alanine (carnosine precursor)
- Muscle carnosine metabolism and beta-alanine supplementation in relation to exercise and trainingReviewHumansWith beta-alanine (carnosine precursor)
- Effect of beta-alanine supplementation on muscle carnosine concentrations and exercise performanceReviewHumansWith beta-alanine (carnosine precursor)
- Carnosine loading and washout in human skeletal musclesRandomised controlled trialHumansWith beta-alanine (carnosine precursor)
- The effect of 4 weeks beta-alanine supplementation and isokinetic training on carnosine concentrations in type I and II human skeletal muscle fibresControlled trialHumansWith beta-alanine (carnosine precursor)
- Beta-alanine improves sprint performance in endurance cyclingRandomised controlled trialHumansWith beta-alanine (carnosine precursor)
- Beta-alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprintersRandomised controlled trialHumansWith beta-alanine (carnosine precursor)
- Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacityControlled trialHumansWith beta-alanine (carnosine precursor)
- The absorption of orally supplied beta-alanine and its effect on muscle carnosine synthesis in human vastus lateralisControlled trialHumansWith beta-alanine (carnosine precursor)
With beta-alanine (carnosine precursor) in separate arms
- Effect of beta-alanine and carnosine supplementation on muscle contractility in miceLaboratory studyOther animalsWith beta-alanine (carnosine precursor) in separate arms
With beta-alanine (carnosine precursor) included alongside carnosine
- Effect of Carnosine or beta-Alanine Supplementation on Markers of Glycemic Control and Insulin Resistance in Humans and Animals: A Systematic Review and Meta-analysisMeta-analysisHumansWith beta-alanine (carnosine precursor) included alongside carnosine
With beta-alanine (carnosine precursor) with L-histidine
- Influence of oral beta-alanine and L-histidine supplementation on the carnosine content of the gluteus mediusOpen-label, no control groupHorsesWith beta-alanine (carnosine precursor) with L-histidine
With beta-alanine (carnosine precursor) with L-histidine (one chapter); other chapters are observational
- Carnosine metabolism and function in the thoroughbred horseObservational studyHorsesWith beta-alanine (carnosine precursor) with L-histidine (one chapter); other chapters are observational
With beta-alanine (carnosine precursor) with resistance training
- The effects of 10 weeks of resistance training combined with beta-alanine supplementation on whole body strength, force production, muscular endurance and body compositionRandomised controlled trialHumansWith beta-alanine (carnosine precursor) with resistance training
With carnosine-magnesium sulphate complex compared with free carnosine
- Evaluation of the transepidermal penetration of a carnosine complex in gel formulation by 3D skin modelsLaboratory studyHumansTopicalWith carnosine-magnesium sulphate complex compared with free carnosine and magnesium alone
With chicken breast extract (carnosine
- Chicken Breast Attenuates High-Intensity-Exercise-Induced Decrease in Rat Sarcoplasmic Reticulum Ca2+ HandlingControlled trialOther animalsWith chicken breast extract (carnosine and anserine source)
With citalopram (both groups
- L-Carnosine combination therapy for major depressive disorder: A randomized, double-blind, placebo-controlled trialRandomised controlled trialHumansWith citalopram (both groups, up to 40 mg per day)
With dietary histidine (carnosine precursor)
- Effect of histidine-free and -excess diets on anserine and carnosine contents in rat gastrocnemius muscleLaboratory studyOther animalsWith dietary histidine (carnosine precursor), not carnosine itself
With histidine (carnosine precursor)
- Increased broiler muscle carnosine and anserine following histidine supplementation of commercial broiler feed concentrateControlled trialOther animalsWith histidine (carnosine precursor)
With histidine (tested in parallel arms)
- Beneficial effects of histidine and carnosine on ethanol-induced chronic liver injuryLaboratory studyOther animalsWith histidine (tested in parallel arms)
- Histidine and carnosine delay diabetic deterioration in mice and protect human low density lipoprotein against oxidation and glycationLaboratory studyOther animalsWith histidine (tested in parallel arms)
With histidine tested in separate arms
- Protective effects from carnosine and histidine on acetaminophen-induced liver injuryLaboratory studyOther animalsWith histidine tested in separate arms
With histidine-containing dipeptides (carnosine
- Histidine-containing dipeptides reduce central obesity and improve glycaemic outcomes: A systematic review and meta-analysis of randomized controlled trialsMeta-analysisHumansWith histidine-containing dipeptides (carnosine, anserine, beta-alanine studies pooled)
With histidine-supplemented diet (used in vivo to raise muscle carnosine)
- In vitro and in vivo inhibition of muscle lipid and protein oxidation by carnosineLaboratory studyOther animalsWith histidine-supplemented diet (used in vivo to raise muscle carnosine)
With L-carnitine in some arms (carnosine-alone arm also included)
- Dietary carnitine and carnosine increase body lean in healthy cats in a preliminary studyControlled trialCatsWith L-carnitine in some arms (carnosine-alone arm also included)
With L-DOPA based standard therapy (both groups)
- Carnosine Increases Efficiency of DOPA Therapy of Parkinson's Disease: A Pilot StudyControlled trialHumansWith L-DOPA based standard therapy (both groups)
With LactiGo gel (carnosine-magnesium complex) applied over a warm-up cream
- Evaluation of the efficacy of Lactigo topical gel as an ergogenic aidOpen-label, no control groupHumansTopicalWith LactiGo gel (carnosine-magnesium complex) applied over a warm-up cream
With N-acetylcarnosine (carnosine prodrug)
- N-Acetylcarnosine, a natural histidine-containing dipeptide, as a potent ophthalmic drug in treatment of human cataractsControlled trialHumansTopicalWith N-acetylcarnosine (carnosine prodrug)
- N alpha-acetylcarnosine is a prodrug of L-carnosine in ophthalmic application as antioxidantLaboratory studyOther animalsTopicalWith N-acetylcarnosine (carnosine prodrug)
With N-acetylcarnosine (carnosine prodrug) 1% eye drops
- Efficacy of N-Acetylcarnosine in the Treatment of CataractsRandomised controlled trialHumansTopicalWith N-acetylcarnosine (carnosine prodrug) 1% eye drops
With N-acetylcarnosine (carnosine prodrug) eye drops
- N-acetylcarnosine (NAC) drops for age-related cataractReviewHumansWith N-acetylcarnosine (carnosine prodrug) eye drops
With N-acetylcarnosine (carnosine prodrug) eyedrops
- N-acetylcarnosine lubricant eyedrops possess all-in-one universal antioxidant protective effects of L-carnosine in aqueous and lipid membrane environments, aldehyde scavenging, and transglycation activities inherent to cataracts: a clinical study of the new vision-saving drug N-acetylcarnosine eyedrop therapy in a database population of over 50,500 patientsControlled trialHumansTopicalWith N-acetylcarnosine (carnosine prodrug) eyedrops
With risperidone (both groups)
- l-Carnosine As an Adjunctive Therapy to Risperidone in Children with Autistic Disorder: A Randomized, Double-Blind, Placebo-Controlled TrialRandomised controlled trialHumansWith risperidone (both groups)
With vigabatrin (antiepileptic drug; homocarnosine was the measured outcome)
- Vigabatrin increases human brain homocarnosine and improves seizure controlOpen-label, no control groupHumansWith vigabatrin (antiepileptic drug; homocarnosine was the measured outcome)
With vitamin E (in some groups)
- Effects of dietary carnosine and vitamin E on antioxidant and oxidative status of ratsLaboratory studyOther animalsWith vitamin E (in some groups)
With zinc (as a zinc L-carnosine compound)
- Effect of a zinc L-carnosine compound on acid-induced injury in canine gastric mucosa ex vivoLaboratory studyDogsWith zinc (as a zinc L-carnosine compound)
With zinc (as polaprezinc / zinc-L-carnosine)
- Protective and Healing Effects of Zinc L-Carnosine on the Oral Mucosa: A Systematic Review and Meta-AnalysisMeta-analysisHumansWith zinc (as polaprezinc / zinc-L-carnosine)
- Efficacy and safety of polaprezinc in the treatment of gastric ulcer: A multicenter, randomized, double-blind, double-dummy, positive-controlled clinical trialRandomised controlled trialHumansWith zinc (as polaprezinc / zinc-L-carnosine)
- Effectiveness of polaprezinc for low-dose aspirin-induced small-bowel mucosal injuries as evaluated by capsule endoscopy: a pilot randomized controlled studyRandomised controlled trialHumansWith zinc (as polaprezinc / zinc-L-carnosine)
With zinc (as polaprezinc / zinc-L-carnosine) added to triple therapy
- Efficacy and Safety of Polaprezinc-Based Therapy versus the Standard Triple Therapy for Helicobacter pylori Eradication: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsMeta-analysisHumansWith zinc (as polaprezinc / zinc-L-carnosine) added to triple therapy
With zinc (as polaprezinc / zinc-L-carnosine) mouth rinse
- Polaprezinc reduces the severity of radiation-induced mucositis in head and neck cancer patientsControlled trialHumansTopicalWith zinc (as polaprezinc / zinc-L-carnosine) mouth rinse
With zinc (as polaprezinc / zinc-L-carnosine); bovine colostrum in two arms
- Zinc carnosine works with bovine colostrum in truncating heavy exercise-induced increase in gut permeability in healthy volunteersRandomised controlled trialHumansWith zinc (as polaprezinc / zinc-L-carnosine); bovine colostrum in two arms
With zinc (as polaprezinc)
- Inhibitory effect of polaprezinc on the inflammatory response to Helicobacter pyloriLaboratory studyOther animalsWith zinc (as polaprezinc)
- Polaprezinc Attenuates Helicobacter pylori-Associated Gastritis in Mongolian GerbilsControlled trialOther animalsWith zinc (as polaprezinc)
- Effect of polaprezinc on impaired healing of chronic gastric ulcers in adjuvant-induced arthritic rats: role of insulin-like growth factors (IGF)-1Controlled trialOther animalsWith zinc (as polaprezinc)
- Polaprezinc exerts a salutary effect on impaired healing of acute gastric lesions in diabetic ratsLaboratory studyOther animalsWith zinc (as polaprezinc)
- Applicability of zinc complex of L-carnosine for medical useReviewHumansWith zinc (as polaprezinc)
- Ulcerogenic and healing impairing actions of monochloramine in rat stomachs: effects of zinc L-carnosine, polaprezincLaboratory studyOther animalsWith zinc (as polaprezinc)
- Effect of polaprezinc (N-(3-aminopropionyl)-L-histidinato zinc), a novel antiulcer agent containing zinc, on cellular proliferation: role of insulin-like growth factor ILaboratory studyOther animalsWith zinc (as polaprezinc)
- Insulin-like growth factor I plays a role in gastric wound healing: evidence using a zinc derivative, polaprezinc, and an in vitro rabbit wound repair modelLaboratory studyOther animalsWith zinc (as polaprezinc)
- Residence time of polaprezinc (zinc L-carnosine complex) in the rat stomach and adhesiveness to ulcerous sitesLaboratory studyOther animalsWith zinc (as polaprezinc)
With zinc (as polaprezinc); ginger extract tested in parallel
- Ginger extract and polaprezinc exert gastroprotective actions by anti-oxidant and growth factor modulating effects in ratsLaboratory studyOther animalsWith zinc (as polaprezinc); ginger extract tested in parallel
With zinc (as zinc carnosine)
- Zinc carnosine, a health food supplement that stabilises small bowel integrity and stimulates gut repair processesLaboratory studyOther animalsHumansWith zinc (as zinc carnosine)
With zinc (as zinc-carnosine complex)
- The dipeptide carnosine constricts rabbit saphenous vein as a zinc complex apparently via a serotonergic receptorLaboratory studyOther animalsWith zinc (as zinc-carnosine complex)
With zinc (zinc(II)-carnosine complexes)
- Raman and IR spectroscopic investigation of zinc(II)-carnosine complexesLaboratory studyOther animalsWith zinc (zinc(II)-carnosine complexes)