Safety evaluation of chicken breast extract containing carnosine and anserine
Laboratory studyOther animalsWith anserine (chicken breast extract containing carnosine and anserine)
This study tested carnosine together with anserine (chicken breast extract containing carnosine and anserine). Its results cannot be assigned to carnosine alone. More combination studies.
- Design
- Laboratory study
- Dose used in the study
- Oral LD50 testing; gavage of 500 or 2000 mg/kg/day chicken breast extract
- Duration
- 90 days
- What was measured
- Acute oral LD50 in rats, 90-day gavage toxicity (body weight, food intake, behaviour, haematology, clinical chemistry, organ weights, gross and microscopic pathology) and Ames mutagenicity testing.
What the authors reported
Chicken breast extract had an oral LD50 above 6000 mg/kg in rats. Gavage at 500 or 2000 mg/kg/day for 90 days produced no toxicologically significant dose-related differences from controls. The extract was not mutagenic in the Ames assay with or without metabolic activation.
Limits of this study
Industry-affiliated authors (Nippon Meat Packers). Rat toxicology of a mixed extract, not purified carnosine. Rodents lack serum carnosinase, so oral results do not carry over to people. Abstract only.
Source
PubMed 17919801 · doi:10.1016/j.fct.2007.08.020
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.