Protective effects from carnosine and histidine on acetaminophen-induced liver injury
Laboratory studyOther animalsWith histidine tested in separate arms
This study tested carnosine together with histidine tested in separate arms. Its results cannot be assigned to carnosine alone. More combination studies.
- Design
- Laboratory study
- Dose used in the study
- 0.5, 1 or 2 g/L in drinking water
- Duration
- 4 weeks
- What was measured
- Hepatic glutathione, ascorbic acid, oxidative stress markers, antioxidant enzyme activities and inflammatory cytokines after acetaminophen 350 mg/kg i.p. in Balb/cA mice.
What the authors reported
Acetaminophen depleted hepatic glutathione and ascorbic acid, raised malondialdehyde, reactive oxygen species and oxidised glutathione, and lowered glutathione peroxidase, catalase and superoxide dismutase (P < 0.05). Pre-intake of carnosine or histidine alleviated these changes, retarded the rise in cytochrome P450 2E1 activity and diminished the rise in IL-6, IL-10, TNF-alpha and MCP-1 (P < 0.05). The authors say the effects may act at the transcription level and describe both as potent hepatoprotective agents.
Limits of this study
Rodents lack serum carnosinase, so oral results do not carry over to people. Full text not read.
Source
PubMed 19799668 · doi:10.1111/j.1750-3841.2009.01330.x
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.