Effect of a zinc L-carnosine compound on acid-induced injury in canine gastric mucosa ex vivo
Laboratory studyDogsWith zinc (as a zinc L-carnosine compound)
This study tested carnosine together with zinc (as a zinc L-carnosine compound). Its results cannot be assigned to carnosine alone. More combination studies.
- Design
- Laboratory study
- Subjects
- gastric mucosa from 6 healthy dogs
- Dose used in the study
- not stated in abstract (compound added to Ussing chamber solution)
- Duration
- 180 minutes ex vivo
- What was measured
- Transepithelial electrical resistance (permeability) and apoptosis (active caspase-3 immunofluorescence) in canine antral mucosa exposed to acidic Ringer's solution (pH 1.5 to 2.5) with or without the zinc L-carnosine compound, or the compound alone.
What the authors reported
The authors report that acid significantly increased mucosal permeability over time, with changes appearing within 15 minutes, and caused apoptosis that was absent in controls. The zinc L-carnosine compound had no significant effect on the acid-induced permeability increase and did not prevent apoptosis. They conclude they found no significant protective effect from the compound in this model, and suggest the model is useful for future canine gastric injury studies.
Limits of this study
Ex-vivo tissue model from six dogs; acid injury model only; compound concentration not stated in the abstract. The result was negative.
Source
PubMed 22533397 · doi:10.2460/ajvr.73.5.659
Entry checked against abstract (University of Minnesota Experts record) on 2026-10-11. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.