Histidine-containing dipeptides reduce central obesity and improve glycaemic outcomes: A systematic review and meta-analysis of randomized controlled trials
Meta-analysisHumansWith histidine-containing dipeptides (carnosine, anserine, beta-alanine studies pooled)
This study tested carnosine together with histidine-containing dipeptides (carnosine, anserine, beta-alanine studies pooled). Its results cannot be assigned to carnosine alone. More combination studies.
- Design
- Meta-analysis
- Subjects
- 30 randomised trials included; 23 pooled
- Dose used in the study
- Varied across included studies
- Duration
- Varied across included studies
- What was measured
- Waist circumference, HbA1c, fasting glucose, fat mass, insulin resistance and insulin secretion. Random-effects weighted mean differences.
What the authors reported
Supplemented groups had lower waist circumference (WMD -3.53 cm, 95% CI -5.65 to -1.41, p = 0.001) and lower HbA1c (WMD -0.76%, 95% CI -1.29 to -0.24, p = 0.004) than controls. In low-risk-of-bias studies, fasting glucose was also lower (WMD -0.63 mmol/L, 95% CI -1.09 to -0.18, p = 0.006). Trends for fat mass, insulin resistance and insulin secretion did not reach significance.
Limits of this study
Pooled different dipeptides and populations. Many included trials were small. Heterogeneity in doses and durations. Full text not read.
Source
PubMed 31828942 · doi:10.1111/obr.12975
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.