Effect of anserine ingestion on hyperglycemia and the autonomic nerves in rats and humans
Controlled trialHumansOther animalsWith anserine (carnosine analogue, tested alone)
This study tested carnosine together with anserine (carnosine analogue, tested alone). Its results cannot be assigned to carnosine alone. More combination studies.
- Design
- Controlled trial
- Dose used in the study
- rats: anserine by intraperitoneal injection (doses not specified in abstract) and 0.1 mg intraduodenal; humans: oral dose not stated in abstract
- What was measured
- Blood glucose and plasma glucagon in rats; sympathetic and vagal nerve activity in rats; blood glucose during an oral glucose tolerance test in humans.
What the authors reported
In rats, anserine reduced hyperglycaemia and plasma glucagon, suppressed sympathetic nerve activity and enhanced vagal gastric efferent activity; thioperamide blocked the hypoglycaemic effect, pointing to a histaminergic pathway. In humans, oral anserine lowered blood glucose during glucose tolerance testing.
Limits of this study
Human arm size, dose and design are not stated in the abstract; rat group sizes and intraperitoneal doses not stated. Anserine, not carnosine, was tested. Full text not read.
Source
PubMed 20670474 · doi:10.1179/147683010X12611460764363
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.