In vitro and in vivo inhibition of muscle lipid and protein oxidation by carnosine
Laboratory studyOther animalsWith histidine-supplemented diet (used in vivo to raise muscle carnosine)
This study tested carnosine together with histidine-supplemented diet (used in vivo to raise muscle carnosine). Its results cannot be assigned to carnosine alone. More combination studies.
- Design
- Laboratory study
- Dose used in the study
- Carnosine 1 to 2.5 mM in vitro; histidine-supplemented diet in vivo
- Duration
- 13 days of histidine feeding
- What was measured
- Lipid peroxidation and protein oxidation in rat hind-limb muscle homogenates exposed to Fenton-generated radicals with carnosine, histidine or beta-alanine; muscle carnosine, lipid peroxidation and protein carbonyls in rats fed histidine then given iron-nitrilotriacetate.
What the authors reported
Carnosine inhibited lipid peroxidation and protein oxidation in muscle homogenates, with minimum effective concentrations of 2.5 and 1 mM respectively; histidine and beta-alanine alone had no effect. Rats fed a histidine-supplemented diet for 13 days showed a marked rise in muscle carnosine and lower muscle lipid peroxidation and protein carbonyls after iron-nitrilotriacetate challenge.
Limits of this study
The in vivo arm fed histidine rather than carnosine, so the dietary route applies to the precursor. Rodents lack serum carnosinase, so oral results do not carry over to people. Abstract only.
Source
PubMed 11716361 · doi:10.1023/a:1012256521840
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.