Effect of histidine-free and -excess diets on anserine and carnosine contents in rat gastrocnemius muscle
Laboratory studyOther animalsWith dietary histidine (carnosine precursor), not carnosine itself
This study tested carnosine together with dietary histidine (carnosine precursor), not carnosine itself. Its results cannot be assigned to carnosine alone. More combination studies.
- Design
- Laboratory study
- What was measured
- Anserine and carnosine content of rat gastrocnemius muscle on histidine-free and histidine-excess diets and after one week of rehabilitation.
What the authors reported
A histidine-free diet lowered muscle anserine and carnosine, with a particularly marked fall in carnosine, and both returned to normal after one week of rehabilitation. On a histidine-excess diet, body and gastrocnemius weight fell, while muscle anserine and carnosine were about twice control levels and urinary excretion of methylhistidines rose.
Limits of this study
Rat feeding study; sample sizes not given in abstract. Rodents lack serum carnosinase, so oral results do not carry over to people. Full text not read.
Source
PubMed 915562 · doi:10.3177/jnsv.23.331
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.