L-carnosine affects the growth of Saccharomyces cerevisiae in a metabolism-dependent manner
Laboratory studyOther animals
- Design
- Laboratory study
- Dose used in the study
- 10 to 30 mM L-carnosine in culture medium
- What was measured
- Growth and cell death of yeast in fermentable (glucose) and non-fermentable (glycerol) media with and without L-carnosine, and the response of nutrient-sensing pathway deletion strains.
What the authors reported
In glucose media (2%), 10 to 30 mM L-carnosine slowed yeast growth in a dose-dependent way and increased cell death by up to 17%. In glycerol media, where yeast depend on respiration, L-carnosine did not cause cell death, and the authors confirmed this in the respiratory yeast Pichia pastoris. Deletion strains of the nutrient-sensing pathway were resistant to its inhibitory effects. The authors say the findings suggest carnosine acts in a metabolism-dependent way.
Limits of this study
Yeast model; relevance to mammalian cells is inferred by the authors. Full text not read.
Source
PubMed 22984600 · doi:10.1371/journal.pone.0045006
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.