Effects of L-carnosine on splenic sympathetic nerve activity and tumor proliferation
Laboratory studyOther animals
- Design
- Laboratory study
- Dose used in the study
- 3.3 mg/kg L-carnosine intraduodenally in rats; 1 mg/mL L-carnosine as the only drinking water in mice
- What was measured
- Splenic sympathetic nerve activity in urethane-anaesthetised rats after intraduodenal L-carnosine, and growth of human colon cancer cells transplanted into athymic nude mice given carnosine in drinking water.
What the authors reported
Intraduodenal L-carnosine at 3.3 mg/kg significantly suppressed splenic sympathetic nerve activity. In nude mice, 1 mg/mL L-carnosine in drinking water inhibited proliferation of transplanted human colon cancer cells. The authors suggest the effect is mediated by increased natural killer activity following reduced splenic sympathetic tone.
Limits of this study
Short report; group sizes and effect sizes not stated in abstract; authors at a commercial research company (ANBAS). Rodents lack serum carnosinase, so oral results do not carry over to people. Abstract only.
Source
PubMed 22240100 · doi:10.1016/j.neulet.2011.12.058
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.