Effect of carnosine on excitation-contraction coupling in mechanically-skinned rat skeletal muscle
Laboratory studyOther animals
- Design
- Laboratory study
- Dose used in the study
- 4, 8 and 16 mM carnosine applied to the cytoplasmic side of skinned fibres
- What was measured
- Calcium sensitivity of the contractile apparatus and force responses to caffeine-induced calcium release and to T-system depolarisation in mechanically skinned rat muscle fibres.
What the authors reported
Carnosine raised the calcium sensitivity of the contractile apparatus in a concentration-dependent way (about +0.02 to +0.09 pCa units at 4, 8 and 16 mM). Force responses to caffeine-induced sarcoplasmic reticulum calcium release and to T-system depolarisation were potentiated in the presence of carnosine. The potentiation was explained by the increased calcium sensitivity; carnosine did not cause additional calcium release from the sarcoplasmic reticulum under physiological conditions.
Limits of this study
Isolated rat fibre preparation; no whole-animal or human data. Abstract only.
Source
PubMed 15467383 · doi:10.1023/b:jure.0000038265.37022.c5
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.