Effects of carnosine on contractile apparatus Ca2+ sensitivity and sarcoplasmic reticulum Ca2+ release in human skeletal muscle fibers
Laboratory studyHumans
- Design
- Laboratory study
- Subjects
- 6 type I and 5 type II fibres from vastus lateralis biopsies
- Dose used in the study
- 8 and 16 mM carnosine in the bathing solution
- What was measured
- Calcium sensitivity of the contractile apparatus (pCa50), caffeine-induced force potentiation and sarcoplasmic reticulum calcium release in mechanically skinned human muscle fibres.
What the authors reported
Carnosine at 8 and 16 mM increased calcium sensitivity, shifting pCa50 by 0.073 and 0.116 in type I fibres and by 0.063 and 0.103 in type II fibres. At 8 mM it potentiated caffeine-induced force responses in both fibre types. In type II fibres this was entirely explained by the rise in calcium sensitivity. In type I fibres the potentiation was beyond what that rise would predict, which the authors take as suggesting increased calcium-induced calcium release. They suggest these actions could help slow the decline in performance during fatiguing stimulation.
Limits of this study
In vitro skinned-fibre preparation from biopsies; carnosine concentrations were set by the experimenters rather than achieved by supplementation. Full text not read.
Source
PubMed 22174397 · doi:10.1152/japplphysiol.01331.2011
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.