Denervation in the primary olfactory pathway of mice. IV. Biochemical and morphological evidence for neuronal replacement following nerve section
Laboratory studyOther animals
- Design
- Laboratory study
- What was measured
- Carnosine, carnosine synthetase activity and olfactory marker protein in mouse olfactory bulb and epithelium after unilateral olfactory nerve section, alongside light and electron microscopy.
What the authors reported
The three markers of olfactory receptor neurons fell rapidly in bulb and epithelium, reaching a minimum by the end of the first week after nerve section, then returned to about 80 percent of control by one month; carnosinase activity in epithelium was unaffected. The biochemical time course matched the degeneration and subsequent regrowth of olfactory axons, consistent with replacement of olfactory neurons from basal stem cells.
Limits of this study
Mouse neuroanatomy study; carnosine is used as a neuronal marker rather than an intervention. Abstract only.
Source
PubMed 890470 · doi:10.1016/0006-8993(77)90703-x
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.