Carnosine supplementation protects rat brain tissue against ethanol-induced oxidative stress
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- 40 male rats in four groups of 10
- Dose used in the study
- 1 mg/kg/day carnosine orally; ethanol 2 g/kg/day intraperitoneally
- What was measured
- Brain malondialdehyde, protein carbonyls, tissue carnosine and superoxide dismutase activity in control, carnosine, ethanol and ethanol plus carnosine groups.
What the authors reported
Ethanol raised brain malondialdehyde and protein carbonyls compared with the other groups. Carnosine lowered malondialdehyde relative to controls, and superoxide dismutase activity was higher in the ethanol plus carnosine group. Brain carnosine was higher in the carnosine, ethanol and combined groups than in controls.
Limits of this study
Low oral dose in rats; duration not stated in abstract. Rodents lack serum carnosinase, so oral results do not carry over to people. Abstract only.
Source
PubMed 20047045 · doi:10.1007/s11010-009-0369-x
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.