Toxic effects of beta-amyloid(25-35) on immortalised rat brain endothelial cell: protection by carnosine, homocarnosine and beta-alanine
Laboratory studyOther animals
- Design
- Laboratory study
- What was measured
- MTT reduction, lactate dehydrogenase release and glucose consumption in RBE4 rat brain endothelial cells exposed to beta-amyloid(25-35) with or without carnosine, beta-alanine, homocarnosine, aminoguanidine or superoxide dismutase.
What the authors reported
Beta-amyloid(25-35) was toxic at 200 microg/mL. Carnosine prevented cell damage completely at 200 microg/mL amyloid and partially at 300 microg/mL. Beta-alanine, homocarnosine, aminoguanidine and superoxide dismutase also partially rescued cells but less effectively than carnosine. The authors attribute protection to anti-glycating and antioxidant actions.
Limits of this study
Immortalised cell line with a truncated amyloid fragment. Abstract only.
Source
PubMed 9533405 · doi:10.1016/s0304-3940(98)00058-5
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.