Carnosine uptake in rat choroid plexus primary cell cultures and choroid plexus whole tissue from PEPT2 null mice
Laboratory studyOther animals
- Design
- Laboratory study
- What was measured
- Carnosine uptake kinetics in rat choroid plexus cell monolayers and in choroid plexus tissue from wild-type and PEPT2 knockout mice.
What the authors reported
Carnosine was taken up mainly from the apical side with limited basolateral efflux. A high-affinity PEPT2-type process had a Km of 34 uM and Vmax of 73 pmol/mg protein/min; a non-saturable component made up about 3% of uptake. PEPT2 accounted for over 90% of carnosine uptake in choroid plexus tissue.
Limits of this study
In vitro and ex vivo rodent tissue (rat cell cultures, mouse tissue). An erratum was published (J Neurochem 2004;91(4):1024). Full text not read.
Source
PubMed 15056281 · doi:10.1111/j.1471-4159.2004.02333.x
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.