PEPT2-mediated transport of 5-aminolevulinic acid and carnosine in astrocytes
Laboratory studyOther animals
- Design
- Laboratory study
- What was measured
- Uptake kinetics of 14C-ALA and 3H-carnosine in cultured neonatal rat astrocytes and in astrocytes from PEPT2 wild-type and knockout mice.
What the authors reported
Carnosine uptake in rat astrocytes was inhibited by dipeptides but not by histidine, was saturable (Vmax 447 pmol/mg/min, Km 43 microM) and pH sensitive. Astrocytes from PEPT2 knockout mice showed a 92 percent reduction in carnosine uptake and a 62 percent reduction in ALA uptake, so PEPT2 is the main transporter for astrocytic carnosine uptake.
Limits of this study
Neonatal astrocyte cultures. Abstract only.
Source
PubMed 17034769 · doi:10.1016/j.brainres.2006.09.013
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.