Calcium-sensitizing function for the dipeptide carnosine in skeletal muscle contractility
Laboratory studyOther animals
- Design
- Laboratory study
- Dose used in the study
- 0.1 to 10 mM carnosine
- What was measured
- Calcium release and tension in skinned skeletal muscle fibres, and open probability and dwell time of single ryanodine receptor channels in lipid bilayers.
What the authors reported
Carnosine released calcium from the sarcoplasmic reticulum and generated tension in skinned fibres, though less potently than caffeine (ED50 6.6 mM versus 1.5 mM). In single ryanodine receptor channels, 0.1 to 10 mM carnosine raised open probability about fourfold with a maximum at 2.5 mM, and 5 mM roughly doubled dwell time. The authors propose carnosine acts as a calcium sensitiser.
Limits of this study
In vitro preparations; species of muscle not stated in abstract. Abstract only.
Source
Entry checked against OpenAlex record (abstract) on 2026-10-17. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.