The carbonyl scavenger carnosine ameliorates dyslipidaemia and renal function in Zucker obese rats
Controlled trialOther animals
- Design
- Controlled trial
- Subjects
- not stated in abstract (non-diabetic Zucker obese rats)
- Dose used in the study
- 30 mg/kg per day of L-carnosine or D-carnosine in drinking water
- Duration
- 24 weeks
- What was measured
- Monthly systolic blood pressure; plasma triglycerides, total cholesterol, glucose, insulin and creatinine; urinary protein, albumin and creatinine; markers of oxidative and carbonyl stress in plasma, urine and kidney; kidney electron microscopy.
What the authors reported
The authors report that both L-carnosine and D-carnosine limited the development of dyslipidaemia, hypertension and renal injury in Zucker obese rats, as shown by urinary parameters and kidney electron microscopy. The two enantiomers had almost identical protective effects. Because D-carnosine is not a histidine precursor and resists hydrolysis, the authors argue that the effects are unlikely to come from a pro-histaminic mechanism and propose direct carbonyl quenching as a contributing mechanism.
Limits of this study
Rat model; group sizes and numerical results are not given in the abstract.
Source
PubMed 20518851 · doi:10.1111/j.1582-4934.2010.01101.x
Entry checked against abstract (University of Milan repository record, AIR) on 2026-10-11. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.