Carnosine and its constituents inhibit glycation of low-density lipoproteins that promotes foam cell formation in vitro
Laboratory studyOther animals
- Design
- Laboratory study
- What was measured
- Glycolaldehyde modification of LDL with and without equimolar carnosine, beta-alanine or L-histidine, and cholesteryl ester accumulation in human monocyte-derived macrophages exposed to the modified LDL.
What the authors reported
Carnosine, beta-alanine and L-histidine each inhibited modification of LDL by glycolaldehyde when present at equimolar concentration to the modifying agent. This was accompanied by inhibition of cholesterol and cholesteryl ester accumulation in human monocyte-derived macrophages incubated with the glycated LDL. The authors suggest carnosine and its constituent amino acids may have therapeutic potential against diabetes-induced atherosclerosis.
Limits of this study
In vitro study with isolated LDL and cultured cells. Full text not read.
Source
PubMed 17316626 · doi:10.1016/j.febslet.2007.01.082
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.