The effect of carnosine treatment on prooxidant-antioxidant balance in liver, heart and brain tissues of male aged rats
Laboratory studyOther animals
- Design
- Laboratory study
- Dose used in the study
- 250 mg/kg carnosine daily, intraperitoneal
- Duration
- 1 month
- What was measured
- Malondialdehyde, diene conjugates, protein carbonyls, glutathione, vitamins E and C, and superoxide dismutase, glutathione peroxidase and glutathione transferase activities in liver, heart and brain of young (5 month) and aged (22 month) male rats.
What the authors reported
Aged rats had higher malondialdehyde and diene conjugates in liver and heart but not brain, higher liver protein carbonyls, and lower liver glutathione, vitamin C and superoxide dismutase. Carnosine treatment lowered the raised malondialdehyde, diene conjugate and protein carbonyl levels and raised vitamin E and superoxide dismutase activity in the liver of aged rats. Heart and brain antioxidants were unchanged by carnosine in aged rats.
Limits of this study
Injected carnosine in rats; effects confined to liver. Group sizes not stated in abstract. Abstract only.
Source
PubMed 19430956 · doi:10.1007/s10522-009-9232-4
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.