Carnosine and related dipeptides as quenchers of reactive carbonyl species: From structural studies to therapeutic perspectives
ReviewOther animals
- Design
- Review
- What was measured
- Review of histidine-containing dipeptides (carnosine, homocarnosine, anserine, balenine) as quenchers of reactive carbonyl species such as HNE and acrolein.
What the authors reported
The authors propose that these dipeptides act by trapping reactive carbonyl species. They report that carnosine detoxified HNE formed spontaneously in rat muscle, detected by LC-ESI-MS/MS, and describe a validated method for monitoring the dipeptides in ageing, diabetes and atherosclerosis.
Limits of this study
Review with the authors' own ex vivo and rat data. Full text not read.
Source
PubMed 16403966 · doi:10.1002/biof.5520240109
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.