Carnosine, a protective, anti-ageing peptide?
ReviewOther animalsHumans
- Design
- Review
- Subjects
- not stated in abstract
- Dose used in the study
- not stated in abstract
- Duration
- not stated in abstract
- What was measured
- Short review of laboratory evidence on carnosine's protective functions beyond antioxidant activity.
What the authors reported
The author summarises reports that carnosine extends the lifespan of cultured human fibroblasts, kills transformed cells, and protects cells against aldehydes and an amyloid peptide fragment. In vitro it inhibits protein glycation, including cross-links, carbonyl groups and advanced glycation end-products, and inhibits DNA-protein cross-linking. The author describes carnosine as an aldehyde scavenger and a likely precursor of lipofuscin, and suggests it may modulate diabetic complications, atherosclerosis and Alzheimer's disease.
Limits of this study
Short narrative review based mainly on cell culture and cell-free experiments. Full text not read.
Source
PubMed 9744078 · doi:10.1016/S1357-2725(98)00060-0
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.