Mood and brain
Published human studies in autism, schizophrenia, depression, cognition in older adults, Parkinson's disease and Gulf War illness.
This page lists published studies. It reports what the authors did and found, with the limits of each study. It is not advice.
31 studies listed, newest first.
- Dietary Carnosine Supplementation in Healthy Human Volunteers: A Safety, Tolerability, Plasma and Brain Concentration StudyOpen-label, no control groupHumans
- Unveiling the hidden therapeutic potential of carnosine, a molecule with a multimodal mechanism of action: a position paperReviewOther animalsHumans
- L-Carnosine combination therapy for major depressive disorder: A randomized, double-blind, placebo-controlled trialRandomised controlled trialHumansWith citalopram (both groups, up to 40 mg per day)
- Carnosine in health and diseaseReviewHumansOther animals
- l-Carnosine As an Adjunctive Therapy to Risperidone in Children with Autistic Disorder: A Randomized, Double-Blind, Placebo-Controlled TrialRandomised controlled trialHumansWith risperidone (both groups)
- Effect of Anserine/Carnosine Supplementation on Verbal Episodic Memory in Elderly PeopleRandomised controlled trialHumansWith anserine (3:1 anserine to carnosine formula)
- Daily Carnosine and Anserine Supplementation Alters Verbal Episodic Memory and Resting State Network Connectivity in Healthy Elderly AdultsRandomised controlled trialHumansWith anserine (carnosine to anserine ratio 1:3)
- Carnosinases, their substrates and diseasesReviewHumansOther animals
- Anserine and carnosine supplementation in the elderly: Effects on cognitive functioning and physical capacityRandomised controlled trialHumansWith anserine (2:1 anserine to carnosine, from chicken meat extract)
- Carnosine Treatment for Gulf War Illness: A Randomized Controlled TrialRandomised controlled trialHumans
- Physiology and pathophysiology of carnosineReviewHumansOther animals
- Carnosine: new concept for the function of an old moleculeReviewHumansOther animals
- A preliminary, randomized, double-blind, placebo-controlled trial of L-carnosine to improve cognition in schizophreniaRandomised controlled trialHumansWith antipsychotic medication (background therapy)
- Carnosine and its possible roles in nutrition and healthReviewOther animalsHumans
- Carnosine Increases Efficiency of DOPA Therapy of Parkinson's Disease: A Pilot StudyControlled trialHumansWith L-DOPA based standard therapy (both groups)
- Free amino acid and dipeptide changes in the body fluids from Alzheimer's disease subjectsObservational studyHumans
- Double-Blind, Placebo-Controlled Study of L-Carnosine Supplementation in Children With Autistic Spectrum DisordersRandomised controlled trialHumans
- Concentrations of free carnosine (a putative membrane-protective antioxidant) in human muscle biopsies and rat musclesObservational studyHumansOther animals
- Carnosine, a protective, anti-ageing peptide?ReviewOther animalsHumans
- Vigabatrin increases human brain homocarnosine and improves seizure controlOpen-label, no control groupHumansWith vigabatrin (antiepileptic drug; homocarnosine was the measured outcome)
- A deletion in the long arm of chromosome 18 in a child with serum carnosinase deficiencyCase seriesHumans
- Inborn errors of carnosine and homocarnosine metabolismCase seriesHumans
- Homocarnosinosis: influence of dietary restriction of histidineCase seriesHumans
- Serum carnosinase deficiency: a non-disabling phenotype?Case seriesHumans
- Homocarnosinosis: lack of serum carnosinase is the defect probably responsible for elevated brain and CSF homocarnosineLaboratory studyHumans
- Neurological disease in a child with carnosinase deficiencyCase seriesHumans
- Carnosinase deficiency: a new variant with high residual activityCase seriesHumans
- Regional distribution of homocarnosine, homocarnosine-carnosine synthetase and homocarnosinase in human brainLaboratory studyHumans
- Homocarnosinosis: increased content of homocarnosine and deficiency of homocarnosinase in brainCase seriesHumans
- A patient with a deficiency of serum-carnosinase activityCase seriesHumans
- Carnosinemia: a new metabolic disorder associated with neurologic disease and mental defectCase seriesHumans