Carnosine, the anti-ageing, anti-oxidant dipeptide, may react with protein carbonyl groups
ReviewOther animals
- Design
- Review
- What was measured
- Published evidence on carnosine and cellular senescence, and a proposed non-enzymic reaction between carnosine and protein carbonyl groups; a preliminary blood pressure experiment in fructose-fed rats.
What the authors reported
The authors argue that the reported delay of senescence and rejuvenation of cultured human fibroblasts by carnosine is not fully explained by its antioxidant, radical-scavenging and metal-chelating actions. They propose that carnosine reacts non-enzymically with protein carbonyl groups, a process they call carnosinylation. A preliminary rat study reported that carnosine suppressed the blood pressure rise associated with fructose feeding.
Limits of this study
Hypothesis-driven review; the rat data are described as preliminary and dose and duration are not given in the abstract. Full text not read.
Source
PubMed 11470131 · doi:10.1016/S0047-6374(01)00272-X
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.