Effect of carnosine against thioacetamide-induced liver cirrhosis in rat
Laboratory studyOther animals
- Design
- Laboratory study
- Dose used in the study
- 2 g carnosine per litre of drinking water; thioacetamide 200 mg/kg intraperitoneally twice weekly
- Duration
- 3 months
- What was measured
- Plasma transaminases, hepatic hydroxyproline, malondialdehyde and diene conjugates, liver glutathione, superoxide dismutase and glutathione peroxidase expression and activity, and liver histology in female Wistar rats.
What the authors reported
Thioacetamide caused fibrosis, raised transaminases, hydroxyproline and lipid peroxides and lowered antioxidants. Carnosine reduced malondialdehyde and diene conjugates but did not alter the raised transaminases, the reduced antioxidants or the histopathological changes, so it did not prevent the cirrhotic process.
Limits of this study
Rat model; largely negative result. Rodents lack serum carnosinase, so oral results do not carry over to people. Abstract only.
Source
PubMed 19958806 · doi:10.1016/j.peptides.2009.11.028
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.