Decreased activity of carnosinase in serum of patients with chronic liver disorders
Observational studyHumans
- Design
- Observational study
- Subjects
- 69 patients with liver disorders plus normal adults
- What was measured
- Serum carnosinase activity in patients with cirrhosis, hepatoma, chronic hepatitis and acute hepatitis compared with healthy adults; correlation with cholinesterase, albumin and liver enzymes.
What the authors reported
Normal serum carnosinase averaged 4.19 (SD 0.95) umol/mL/h. Activity was markedly lower in cirrhosis (0.51, n=17) and hepatoma (0.68, n=7), moderately lower in chronic hepatitis (1.41, n=17) and within normal limits in acute hepatitis (3.41, n=14). Activity correlated with cholinesterase (r=0.70) and albumin (r=0.59) but not with creatine kinase, AST or ALT. Carnosinase differed more among disorder groups than cholinesterase or albumin did. The authors suggest it may help assess the severity of chronic liver-cell damage but not distinguish liver disease from nutritional, muscle or endocrine disorders.
Limits of this study
Observational; number of healthy adults not stated in the abstract. Full text not read.
Source
PubMed 3731453 · doi:10.1093/clinchem/32.8.1563
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.