Protective effect of orally administered carnosine on bleomycin-induced lung injury
Controlled trialOther animals
- Design
- Controlled trial
- Dose used in the study
- 150 mg/kg/day carnosine by oral bolus
- Duration
- 1 week after bleomycin
- What was measured
- Bronchoalveolar lavage cell counts, TGF-beta, lung histology, immunohistochemistry and apoptosis in mice given intratracheal bleomycin.
What the authors reported
After intratracheal bleomycin, mice given oral carnosine had less lung damage and inflammation than bleomycin controls at one week. The authors report reductions in body weight loss, mortality, neutrophil infiltration (myeloperoxidase and lavage cell counts), lung oedema, histological injury and collagen deposition, lavage TGF-beta, several immunostaining markers and apoptosis. Numeric outcome values are not given in the abstract.
Limits of this study
Group sizes not stated in abstract. Rodents lack serum carnosinase, so oral results do not carry over to people. Full text not read.
Source
PubMed 17220373 · doi:10.1152/ajplung.00283.2006
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.