Systematic review and stratified meta-analysis of the efficacy of carnosine in animal models of ischemic stroke
Meta-analysisOther animals
- Design
- Meta-analysis
- Subjects
- 8 publications, 29 comparisons, 454 animals
- Dose used in the study
- varied across studies; the authors report a clear dose-response relationship
- Duration
- varied; efficacy fell when carnosine was given more than 6 hours after ischaemia
- What was measured
- Infarct volume and neurological score in in-vivo rodent ischaemic stroke models; study quality (median 4 of 9) and publication bias.
What the authors reported
The authors report that carnosine reduced infarct volume by 29.4% (95% CI 24.0% to 34.9%) across 29 comparisons. A clear dose-response effect was seen, and efficacy dropped when treatment was given more than 6 hours after ischaemia onset. They conclude that carnosine given before or after ischaemia showed strong efficacy in experimental stroke.
Limits of this study
The authors state that some included studies were of low quality (median quality score 4 of 9) and that all testing used healthy young male animals.
Source
Entry checked against abstract (White Rose Research Online repository record) on 2026-10-11. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.