A re-evaluation of the antioxidant activity of purified carnosine
Laboratory studyOther animals
- Design
- Laboratory study
- What was measured
- Peroxyl radical scavenging, liposome oxidation with copper or iron, and aldehyde adduct formation using carnosine purified to remove hydrazine contamination.
What the authors reported
Earlier commercial carnosine preparations contained hydrazine. Purified carnosine still scavenged peroxyl radicals and inhibited phosphatidylcholine liposome oxidation, more strongly with copper than iron, which the authors attribute to copper chelation. It formed adducts with aldehydic lipid oxidation products, most with alpha,beta-monounsaturated aldehydes, then polyunsaturated and saturated ones. Adduct formation was lower than with glutathione, but the authors expect carnosine's higher concentration in skeletal muscle to make it the most important aldehyde-adduct former there. In oxidising muscle, carnosine oxidation came only in the later stages, which the authors say suggests it may be a less effective free radical scavenger in vivo than antioxidants such as alpha-tocopherol.
Limits of this study
Chemical model systems. Full text not read.
Source
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.