Carnosine, histidine, and wound healing
Controlled trialOther animals
- Design
- Controlled trial
- Dose used in the study
- 1 mg/100 g body weight/day carnosine or histidine, intraperitoneal
- Duration
- 7 days
- What was measured
- Skin breaking strength, collagen deposition in implanted sponges, tissue carnosine and free histidine in rats fed 100% or 50% of required histidine.
What the authors reported
Rats fed the lower histidine intake (50% of requirement) grew less well and, 7 days after wounding, had lower skin-breaking strength, collagen deposition and tissue free histidine and carnosine. Histidine or carnosine injections raised tissue free histidine and brought strength and collagen up to normal in those rats, but did not improve healing further in histidine-sufficient rats. Carnosine was similar to histidine, but slightly better. The authors suggest an interaction between carnosine and stress and that carnosine acts as a histidine reserve for histamine synthesis during trauma.
Limits of this study
Injection route; animal numbers not stated in abstract. Full text not read.
Source
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.