Action of carnosine and beta-alanine on wound healing
Controlled trialOther animalsTopical
- Design
- Controlled trial
- What was measured
- Tensile strength of incision wounds in rats given hydrocortisone to suppress healing, after local carnosine, beta-alanine, histidine or combined treatment.
What the authors reported
In rats given hydrocortisone to suppress healing, local carnosine significantly increased skin tensile strength at incision wounds compared with untreated animals. Beta-alanine plus histidine had a similar effect, but beta-alanine alone did not. Carnosine also significantly increased granulation suppressed by cortisone, mitomycin C, 5-fluorouracil and bleomycin. The authors attribute the effect to histamine derived from carnosine stimulating early effusion and to beta-alanine stimulating collagen synthesis.
Limits of this study
Doses and animal numbers not stated in abstract. Full text not read.
Source
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.