Preventive effect of L-carnosine on ischemia/reperfusion-induced acute renal failure in rats
Laboratory studyOther animals
- Design
- Laboratory study
- Dose used in the study
- 1 or 10 microg/kg L-carnosine intravenously before ischaemia; the higher dose also tested 5 minutes after reperfusion
- What was measured
- Renal function and histology one day after 45 minutes of renal artery and vein occlusion in uninephrectomised rats, and norepinephrine in renal venous plasma after reperfusion.
What the authors reported
Pre-ischaemic L-carnosine dose-dependently attenuated the renal dysfunction and significantly reduced the histological damage at both doses. Norepinephrine in renal venous plasma rose sharply within 2 minutes of reperfusion in untreated rats and was significantly depressed by 10 microg/kg carnosine. Carnosine given 5 minutes after reperfusion gave only moderate improvement. The authors attribute the protection to suppression of renal sympathetic nerve activity.
Limits of this study
Rat model with intravenous microgram doses; group sizes not stated in abstract. Abstract only.
Source
PubMed 12921872 · doi:10.1016/s0014-2999(03)02079-x
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.