Protective effects of carnosine, homocarnosine and anserine against peroxyl radical-mediated Cu,Zn-superoxide dismutase modification
Laboratory studyOther animals
- Design
- Laboratory study
- What was measured
- Fragmentation, inactivation, copper release, carbonyl formation and amino acid oxidation of human Cu,Zn-superoxide dismutase exposed to peroxyl radicals from AAPH, with and without carnosine, homocarnosine or anserine.
What the authors reported
AAPH-derived peroxyl radicals fragmented and inactivated Cu,Zn-SOD. Carnosine, homocarnosine and anserine significantly inhibited the fragmentation and inactivation, the release of copper ions, carbonyl formation and oxidation of amino acid residues; they also inhibited fragmentation of a protein lacking copper. The authors attribute the protection to copper chelation and peroxyl radical scavenging.
Limits of this study
In vitro protein chemistry. Abstract only.
Source
PubMed 11985892 · doi:10.1016/s0304-4165(02)00158-7
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.