Renoprotective effects of l-carnosine on ischemia/reperfusion-induced renal injury in rats
Laboratory studyOther animals
- Design
- Laboratory study
- Dose used in the study
- 1.5 and 5 pmol/rat L-carnosine intracerebroventricularly; 15 nmol/rat intravenously
- What was measured
- Renal sympathetic nerve activity during ischaemia and renal function 24 hours after 45 minutes of renal ischaemia and reperfusion in uninephrectomised rats, with L-carnosine, N-acetylcarnosine, L-histidine, a histamine H3 antagonist or an H3 agonist.
What the authors reported
Intracerebroventricular L-carnosine dose-dependently suppressed the rise in renal sympathetic nerve activity during ischaemia and the renal injury at 24 hours. N-acetylcarnosine, which resists carnosinase, had no effect, while L-histidine was protective; the H3 antagonist thioperamide abolished the protection by intravenous carnosine and an H3 agonist reproduced it. The authors conclude the renoprotection depends on conversion of carnosine to histidine and histamine acting on central H3 receptors.
Limits of this study
Rat model with central and intravenous dosing at picomole to nanomole amounts. Abstract only.
Source
PubMed 16916994 · doi:10.1124/jpet.106.110122
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.