Oral carnosine supplementation prevents vascular damage in experimental diabetic retinopathy
Laboratory studyOther animals
- Design
- Laboratory study
- Dose used in the study
- 1 g/kg body weight/day
- Duration
- 6 months
- What was measured
- Retinal vascular damage, reactive oxygen species, advanced glycation end-products, Hsp27, glial activation, angiopoietin-2 and photoreceptor numbers in streptozotocin-diabetic Wistar rats.
What the authors reported
Oral carnosine prevented retinal vascular damage over 6 months of hyperglycaemia. The protection was not linked to reduced reactive oxygen species or AGE formation; it was associated with increased Hsp27, activated glial cells and normalised Ang-2. The abstract also reports a reduction in photoreceptors in treated animals.
Limits of this study
Rat model; sample size not stated in abstract. Rodents lack serum carnosinase, so oral results do not carry over to people. Full text not read.
Source
PubMed 21865855 · doi:10.1159/000331721
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.