Carnosine and anserine act as effective transglycating agents in decomposition of aldose-derived Schiff bases
Laboratory studyOther animals
- Design
- Laboratory study
- What was measured
- Decomposition of preformed aldosamines (Schiff bases such as glucosyl-lysine) by carnosine and anserine in vitro.
What the authors reported
Carnosine and anserine decomposed the first intermediates of non-enzymatic glycation (aldose-derived Schiff bases) by nucleophilic attack on the preformed aldosamine, a mechanism the author terms transglycation. This is proposed as a second route, beyond acting as competing glycation targets, by which the dipeptides retard or reverse glycation.
Limits of this study
In vitro chemistry; the author states physiological relevance remains to be shown. Abstract only.
Source
PubMed 16112643 · doi:10.1016/j.bbrc.2005.08.033
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.