Ability of carnosine and other skeletal muscle components to quench unsaturated aldehydic lipid oxidation products
Laboratory studyOther animals
- Design
- Laboratory study
- Dose used in the study
- 5 mM carnosine against 0.5 mM aldehyde
- Duration
- 1 hour at 40 degrees C, pH 7.4
- What was measured
- Headspace trans-2-hexenal and 4-hydroxy-2-nonenal (HNE) remaining after incubation with carnosine, its constituent amino acids, other histidine-containing dipeptides, spermine, spermidine, glutathione and thioctic acid.
What the authors reported
Carnosine quenched alpha,beta-monounsaturated aldehydes and HNE more effectively than its constituent amino acids, and at 5 mM reduced headspace trans-2-hexenal (0.5 mM) by 44% after 1 hour. Other histidine-containing dipeptides, spermine and spermidine had similar or slightly lower activity. Glutathione and thioctic acid quenched better, but the authors say their overall contribution is limited by their lower concentration in skeletal muscle.
Limits of this study
Cell-free chemical system aimed at muscle foods. Full text not read.
Source
PubMed 10563848 · doi:10.1021/jf980780j
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.