Carnosine-related dipeptides in the mammalian brain
ReviewOther animals
- Design
- Review
- What was measured
- Review of the distribution of carnosine-related dipeptides in the mammalian brain, including olfactory receptor neurons, glial and ependymal cells and the subependymal layer.
What the authors reported
High carnosine expression in olfactory receptor neurons led to the proposal of a neurotransmitter or modulator role in olfaction, which the authors state has not been fully demonstrated and does not explain the presence of the dipeptides in glial and ependymal cells. Carnosine-like immunoreactivity in the rodent subependymal layer, a region of adult neurogenesis, suggests a role in structural plasticity, although the distribution argues against a direct link to cell migration or renewal. No unified theory of function is available.
Limits of this study
Narrative review. Abstract only.
Source
PubMed 10501633 · doi:10.1016/s0301-0082(99)00010-6
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.