Effects of L-carnosine on renal sympathetic nerve activity and DOCA-salt hypertension in rats
Laboratory studyOther animals
- Design
- Laboratory study
- Dose used in the study
- 1 microg L-carnosine intravenously for nerve recording; diet containing 0.0001 or 0.001 percent L-carnosine for blood pressure
- What was measured
- Renal sympathetic nerve activity in urethane-anaesthetised rats after intravenous L-carnosine, and blood pressure in DOCA-salt hypertensive rats fed carnosine-containing diets.
What the authors reported
Intravenous L-carnosine (1 microg) inhibited renal sympathetic nerve activity, and diets containing 0.0001 or 0.001 percent L-carnosine reduced the rise in blood pressure in DOCA-salt hypertensive rats. The authors propose carnosine released from skeletal muscle as an endogenous blood pressure regulator.
Limits of this study
Short report; group sizes and magnitudes not stated in abstract. Rodents lack serum carnosinase, so oral results do not carry over to people. Abstract only.
Source
PubMed 12132650 · doi:10.1016/s1566-0702(02)00048-6
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.