Detection, characterisation, and quantification of carnosine and other histidyl derivatives in cardiac and skeletal muscle
Laboratory studyOther animals
- Design
- Laboratory study
- What was measured
- Reverse-phase HPLC identification and quantification of carnosine, anserine and their N-acetyl forms and related imidazoles in frog and mammalian cardiac muscle and in skeletal muscle.
What the authors reported
Skeletal muscle carnosine and anserine were separated and measured at concentrations matching published values. Frog heart contained N-acetylhistidine and its 1-methyl derivative. Mammalian cardiac muscle held low carnosine but substantial N-acetyl forms of histidine, 1-methylhistidine, carnosine and anserine, totalling about 10 mM, which the authors state is enough to alter the calcium sensitivity of the contractile apparatus.
Limits of this study
Analytical tissue study. Abstract only.
Source
PubMed 3263885 · doi:10.1016/0304-4165(88)90015-3
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.