Vasodilatory actions of the dietary peptide carnosine

Ririe DG, Roberts PR, Shouse MN, et al.. Nutrition, 2000; 16(3):168-172.

Laboratory studyOther animals

Design

Laboratory study

Dose used in the study

0.625 to 20 mM carnosine applied to isolated aortic rings

What was measured

Relaxation of phenylephrine-preconstricted rat thoracic aortic rings by carnosine, L-histidine or beta-alanine, with and without endothelium and with the guanylate cyclase inhibitor methylene blue; cyclic GMP content.

What the authors reported

Carnosine produced dose-dependent, endothelium-independent relaxation; L-histidine had no effect and beta-alanine caused dose-dependent constriction. Methylene blue reduced the relaxation and lowered cyclic GMP from 65.3 to 8.6 fmol/mg protein, so the effect is at least partly mediated by cyclic GMP.

Limits of this study

Isolated vessel preparation at millimolar concentrations. Abstract only.

Source

PubMed 10705070 · doi:10.1016/s0899-9007(99)00268-3

Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.