Effect of carnosine on age-induced changes in senescence-accelerated mice
Laboratory studyOther animals
- Design
- Laboratory study
- What was measured
- Survival, brain TBARS, MAO-B, Na/K-ATPase activity and NMDA receptor glutamate binding in SAMP1 senescence-accelerated mice given carnosine.
What the authors reported
Carnosine raised the 50% survival time by 20% versus controls and increased the number of animals reaching old age. Treated mice had lower TBARS and MAO-B, reduced Na/K-ATPase activity and increased glutamate binding to NMDA receptors, which the authors link to less lipid peroxidation and membrane protein damage.
Limits of this study
Accelerated-ageing mouse strain; dose not stated in abstract. Rodents lack serum carnosinase, so oral results do not carry over to people. Abstract only.
Source
Entry checked against OpenAlex record (abstract) on 2026-10-17. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.