Carnosine is a novel peptide modulator of intracellular calcium and contractility in cardiac cells
Laboratory studyOther animals
- Design
- Laboratory study
- Dose used in the study
- 1-10 mM in perfusate
- What was measured
- Contractility of isolated perfused rat hearts, free calcium in isolated myocytes, and tension in skinned myocardial fibres exposed to carnosine.
What the authors reported
Carnosine increased contractility dose-dependently (1 to 10 mM) in isolated perfused rat hearts and raised free calcium in isolated myocytes. In skinned myocardial fibres it increased tension via calcium release from the ryanodine receptor channel, and in lipid bilayers it increased the open-state probability and dwell time of the isolated channel. The authors also report it sensitises contractile proteins to calcium, and propose a role as a modulator of intracellular calcium and contractility.
Limits of this study
Isolated rat heart and cell preparations at millimolar concentrations. Full text not read.
Source
PubMed 9038968 · doi:10.1152/ajpheart.1997.272.1.H462
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.