Allelic variation in the CNDP1 gene and its lack of association with longevity and coronary heart disease
Observational studyHumans
- Design
- Observational study
- Subjects
- 1382 individuals (German centenarians, premature coronary heart disease patients and matched controls)
- What was measured
- Frequency of CNDP1 leucine-repeat alleles and other variants in centenarians, patients with premature coronary heart disease and controls.
What the authors reported
The 5-leucine allele, previously linked to protection from diabetic nephropathy, was the most common allele in all groups, with no difference in allele or genotype frequency between centenarians and controls or between coronary patients and controls. New variants were found, including a rare 8-leucine allele, a duplication and a frameshift deletion (L17fsX20) whose homozygosity, estimated at about 1 in 20,000, would be expected to cause carnosinaemia.
Limits of this study
Genetic association study in one population; negative result. Abstract only.
Source
PubMed 16965804 · doi:10.1016/j.mad.2006.08.002
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.